While studying engineering at the University of Pittsburgh, Joe researched many of the surface science principles that Aruga technology is based on. In 2015 he joined a research collaboration between Pitt's chemical engineering department and the University of Pittsburgh Medical Center's (UPMC) vascular surgery group. As the group's research on improved vascular implants developed, so did the commercial vision for the technology. Ultimately, Joe spun Aruga out of the University of Pittsburgh in Spring of 2018 and is a cofounder and the CEO.

 After Luka graduated from the University of Chicago with his M.D. in surgery and a Ph.D. in physical chemistry in 2011, he performed his residency in general surgery at the University of Pittsburgh Medical Center. During his residency he became integral in the research collaboration between Pitt and UPMC and is the first author on both of the group's publications. As the primary inventor of Aruga technology he identified the commercial impact of the work being done and began translating the technology out of the academic setting. Luka is a cofounder and the Chief Technology Officer at Aruga while also being a associate research professor at The University of Chicago Pritzker School of Medicine.

Dr. Edith Tzeng is the Chief of Vascular Surgery at the Pittsburgh Veterans Hospital and a Professor of Surgery at the University of Pittsburgh Medical School. 

Dr. Robert Kormos is the Division Vice President of Global Medical Affairs & Heart Failure at Abbott Laboratories in Austin, TX. He was formerly the Director of the UPMC Artificial Heart Program and Co-Director of the UPMC Heart Transplantation Program.

Dr. Ross Milner is the Director of Aortic Diseases at the University of Chicago.